Module manager: John Huntriss
Email: j.huntriss@leeds.ac.uk
Taught: Semester 2 (Jan to Jun) View Timetable
Year running 2026/27
See programme entry requirements
This module is not approved as an Elective
In this module you will addresses the molecular biology, genetic and epigenetic concepts related to Assisted Reproduction Technology (ART) and reproduction. This module provides you with a theoretical understanding of the techniques used in preimplantation genetic testing (PGT) that are used for the screening, diagnosis and avoidance of inherited genetic disease. You will learn about the developmental, genetic and epigenetic themes that are relevant to reproduction and early development, infertility, and ARTs and look to the emerging developments in these areas that are informed by the latest research. Key features are the exploration of scenarios in genetics, epigenetics and associated research areas related to ART.
This module aims to equip students with an in-depth understanding of areas of genetic testing and molecular biology in the context of Assisted Reproductive Technologies (ARTs).
The specific focus areas include:
1. Preimplantation Genetic Testing (PGT): You will be able demonstrate a thorough understanding of techniques involved in embryo biopsy, and other ART procedures related to obtaining cells and/or genetic material from embryos and gametes. You will be able to demonstrate a comprehensive knowledge of the theories and practices underpinning PGT for the purpose of diagnosis of inherited genetic disease and for screening embryos for the avoidance of genetic/chromosomal abnormality.
2. Advanced molecular embryology: In-depth examination of the molecular biology of preimplantation development and gametogenesis informed by the latest research papers and the applications of technologies including single cell analysis, stem cell technology and in vitro gametogenesis.
3. Epigenetics, Infertility and ART: Critical examination of the potential ramifications of ART methods, as well as infertility itself, on embryo growth and health and development in the short and long term, emphasising the role and importance of developmental epigenetic processes.
Learning Activities
Learning and Teaching Activities: Students will learn through in person lectures, tutorials and seminars and are further supported through online material available on Minerva.
How It Achieves the Objective: These lectures will provide in-depth explanations and demonstrations, enabling students to understand key concepts and techniques. Tutorials address specific problems and allow you to revise and consolidate understanding of module content with tutor guidance, reinforcing your learning with activity-based approaches. Seminars allow discussion and exploration of specific subjects. Online material is provided to you on Minerva to support your independent online learning.
Upon successful completion of the module, you will be able to:
1. Preimplantation Genetic Testing (PGT): Comprehend and discuss methods used for cellular biopsy and molecular genetic diagnosis in PGT, critically evaluating the use of PGT for the diagnosis and screening of human genetic and chromosomal disorders across past, present, and future ART practices.
2. Advanced Molecular Embryology: Critically evaluate and assess the advanced molecular biological methods and technologies that are used in the study of preimplantation embryos, stem cells and gametes and analyse the value of these technologies in researching early embryo development and in developing novel fertility treatments, such as in vitro gametogenesis.
3. Epigenetics, Infertility, and ART: Explain the role and significance of epigenetic processes in gametogenesis, preimplantation development, pregnancy, and later life stages and evaluate the implications for ART practice.
Skills Learning Outcomes
Upon successful completion of the module, you will be able to:
1. Academic Skills: Demonstrate mastery of structured, clear, concise, evidence based academic writing using precise academic language, and critical evaluation of the literature related to preimplantation genetic testing, advanced molecular embryology concepts and epigenetics mechanisms
2. Work Ready Skills: Develop a comprehensive understanding of the theory behind advanced laboratory approaches that are used in research laboratories and in ART laboratories to study the molecular biology of the embryo and achieve genetic screening and diagnosis.
This module examines the molecular, genetic, and epigenetic foundations of Assisted Reproductive Technologies (ART). Students will explore preimplantation genetic testing (PGT), including techniques for embryo biopsy and molecular diagnostics for inherited genetic and chromosomal disorders. The curriculum also covers advanced molecular embryology, focusing on gametogenesis and preimplantation development, informed by cutting-edge technologies such as single-cell analysis, stem cell research, and in vitro gametogenesis. The role of epigenetic processes in reproduction, infertility, and ART is critically analysed, with emphasis on their implications for embryo health and development.
Teaching is delivered through in-person lectures, tutorials, and seminars, supported by online resources via Minerva. Lectures provide theoretical foundations, tutorials consolidate learning, and seminars enable deeper exploration of advanced topics. Assessments focus on the critical evaluation of genetic and molecular technologies, combining theoretical understanding with practical applications relevant to ART.
| Delivery type | Number | Length hours | Student hours |
|---|---|---|---|
| Lecture | 4 | 1.5 | 6 |
| Lecture | 7 | 1 | 7 |
| Seminar | 1 | 0.5 | 0.5 |
| Seminar | 1 | 1.5 | 1.5 |
| Independent online learning hours | 67 | ||
| Private study hours | 68 | ||
| Total Contact hours | 15 | ||
| Total hours (100hr per 10 credits) | 150 | ||
1. Formative Feedback Opportunities
A variety of formative feedback methods will be used to monitor and support student learning throughout the module. These include questioning and quizzes, which will be used to assess student comprehension, identify learning needs, and track academic progress during lectures and other sessions. Additionally, students will have access to online formative MCQs
2. Recap and Module Tutorial
A recap and tutorial session will be held at the end of the module. In this session, students will analyse and discuss various clinical scenarios related to the module content, providing an opportunity to assess and deepen their understanding. Students will also be encouraged to raise questions and participate in interactive discussions on any aspect of the module. The aim of this session is to assess student progress, address any uncertainties, and consolidate academic skills in preparation for the summative assessment.
3. Assessment Scaffolding
A key formative feedback opportunity in the module involves scaffolding the assessment process through early-stage guidance. This opportunity for formative feedback during written coursework preparation will be provided via methods such as a whiteboard session on Minerva and/or feedback on a draft/outline of the essay. This allows you to discuss the essay topics, to aid preparation, to contextualise the essay and for students to ask questions related to preparation. This early engagement allows tutors to offer advice on the relevant literature and areas of relevance, helping students align their work with module assessment expectations from the outset.
| Assessment type | Notes | % of formal assessment |
|---|---|---|
| Coursework | Examine theoretical competence and understanding of module material | 100 |
| Coursework | Formative preparation - Formative tasks for preparation of coursework | 0 |
| Total percentage (Assessment Coursework) | 100 | |
Format: Students will sit a 2,000 word coursework essay. Student Choice: Students will be given a choice of essay titles.
Check the module area in Minerva for your reading list
Last updated: 30/04/2026
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